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Coronary artery and microvascular disease diagnostics

Two American Heart Association grants awarded to Dr. Banerjee focus on the important area of coronary stenoses (Figure 1) diagnostics, which, at present, is primarily dependent on angiographic evidence of stenosis rather than the more deterministic hemodynamic endpoints. This research is aimed towards improving the cardiovascular diagnostics using guidewires during heart attacks.











Through these awards, Dr. Banerjee has introduced a novel coronary diagnostic index, the so-called lesion flow coefficient, which seeks to fulfill the longstanding need for a quantitative parameter that enables simultaneous and combined assessment of pressure gradient, blood flow (Figure 2) and geometric information for any coronary stenosis.  Such an index would enable clinicians to make significant advancements in patient diagnosis and prognosis following percutaneous transluminal coronary angioplasty (PTCA) or bypass surgery by isolating the effects of epicardial stenosis from microvascular impairments.  This research has the potential to improve clinical decision making by using the lesion flow coefficient, and thus, improving on the guidelines for optimal patient care.














Physiologic and pathophysiologic hemodynamic measurements are also obtained using in vitro test sections using guidewires. In conjunction with in vivo study, this lab is well equipped to conduct numerical analyses for validation as well as prediction of flow dynamics inside in vitro models.




Fig 3: Photograph of LAD stenotic model test section (64% or moderate area stenosis). The model is manufactured with optical grade lexan plastic. This figure shows the proximal vessel, converging section, minimal throat section, diverging section, and distal pressure recovery section. The numbered external radial pressure sensor ports along the axial direction are shown in the figure.


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by zopeown last modified 2015-01-23 15:18